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On 5 October 2015, Alkarama sent an urgent action to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the arrest and subsequent disappearance, on 13 September 2015, of two young brothers, Anas and Azzam Magdy Abdelfattah Mahmoud Allam, by the Homeland Security and the General Investigations Department.

On 24 September 2015, Alkarama sent an urgent appeal to the United Nations Special Rapporteur on torture and other cruel, inhuman or degrading treatment or punishment (SRT) regarding the arrest of 32-year-old freelance journalist Hassan Mahmoud Ragab El Kabany in January 2015.

On 24 September 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the disappearance of 17-year-old Khaled Mohamed El Beltagy following his abduction by the Security Forces on 22 September 2015.

On 23 September 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID), regarding the respective abductions of Taalat Hosni Quranu Ali Al Sharkawy and Abdelrahman Mohammed Abdelbasser by the Homeland Security and the Central Security Forces in August and September 2015.

On 22 September, Alkarama sent a communication to the United Nations Special Rapporteur on torture and other cruel, inhuman or degrading treatment or punishment (SRT) regarding the case of Ahmed Raafat Al Sayed Ali , a 20-year-old student who was arrested by the General Investigations in May 2014.

On 17 September 2015, Alkarama sent an urgent appeal to the United Nations Special Rapporteur on the Independence of Judges and Lawyers (SRIJL) regarding the arrest and detention of the head of the legal team defending nearly 500 individuals sentenced in Egypt's biggest mass trial of civilians before a military court. 54-year-old lawyer, Abdelmaksoud Ahmed Abdelmaksoud El Damanhoury was arrested by the Homeland Security in Damanhour in September 2015.

On 11 September 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the case of sales director Hosni Talaat Mohammed Al Nagar, detained incommunicado since his arrest by the 10th of Ramadan Homeland Security in July 2015.

On 2 September 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the cases of 20-year-old student, Abdelrahman Attef Hussein and 31-year-old employee Hani Said Kahla, both disappeared since their respective arrests by the police on 11 July and 19 August 2015.

On 28 August 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced and Involuntary Disappearances (WGEID) regarding the abduction of Mohamed Abdelaziz Farag, 54, his 18-year-old son, Abdelaziz Mohammed Abdelaziz Farag, and his 61-year-old brother, Ismael Abdelaziz Farag. All disappeared following their abduction, from their home in Shubra, by the Homeland Security on 23 August 2015.

On 3 September 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the enforced disappearance of journalist and member of the Muslim Brotherhood, Mosab Abdalla Abdelhamid Morsy Hamed, in early July 2015.