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On 28 April 2016, Alkarama wrote to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the case of two Yemeni citizens, Mujahed Mohamed Ahmed Al Hamdani and Abdulrahman Saeed Hasan Al-Buriahi, who disappeared after their abduction by the Special Security Forces of the military and the Houthi-Saleh Coalition respectively.

Alkarama welcomes the release, on 20 April 2016, of Abdulrab Ahmed Abdulrab Al Humaiqani, a human rights and political activist who was arrested by the Houthi-Saleh Coalition on 28 August 2015. After being arrested without a warrant nor being presented with the reasons for the arrest, Al Humaiqani was taken to an unknown location, where he was kept without contact with his family until his release.

On 5 May 2012, 22-year-old student Rachid Qasim Mohamed Ali Yahya Al Daifi was arrested during a raid by the police forces in Sanaa's Tahrir Square and brought to an unknown location.

On 23 January 2004, as 22-year-old student Wasif Hassan Abdulrab Matar went swimming on the Gold Mohur Coast in the south of Yemen, he was arrested by members of the Yemeni Republican Guards conducting a naval exercise and taken to an unknown location. As he has been missing since, on 27 November 2015, Alkarama sent a communication to the United Nations Working Group on Enforced Disappearances (WGEID), hoping that this human rights mechanism could help shed light on Wasif's fate and whereabouts.

On 10 November 2015, activists Walid Ali Omar Al Kathiri and Abdullah Karash were released by the Houthi-Saleh coalition from the Political Security Prison. Walid Ali Omar Al Kathiri and Abdullah Karash were detained incommunicado since their arrest together with 27 other activists on 12 October 2015 for organising a peaceful march to the besieged city of Taiz.

On 13 November 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the case of Abdulrab Ahmed Abulrab Al Humaiqani, arrested in August 2015 by a group of men belonging to the Houthi-Saleh Coalition. Aged 36, Al Humaiqani works for the governorate of Sana'a and is a human rights and political activist as well as a researcher in international law.

Between 29 October and 2 November 2015, activists Mahmoud Yassin and Mohamed Ali Aboud Al Maliki were released by the Houthi-Saleh Coalition, after being detained incommunicado for more than two weeks at the Political Security Prison. Mahmoud and Mohamed had been arrested with 27 other activists by the Houthi-Saleh Coalition in October for organising a peaceful march to provide drinking water to the population of the besieged city of Taiz.

Between 20 and 30 October 2015, Alkarama sent an urgent appeal the United Nations Working Group on Arbitrary Detention (WGAD) as well as two urgent appeals to the UN Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the cases of three Yemeni citizens unlawfully arrested by the Houthi-Saleh Coalition for criticising the group's policies.

On 21 October 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Arbitrary Detention (WGAD) regarding the case of 29 activists arrested on 12 October 2015 by the Houthi-Saleh Coalition in the central Yemeni city of Ibb during an open meeting held to prepare a peaceful march organised to provide drinking water to the population of the besieged city of Taiz.

On 27 October 2015, Alkarama sent a communication to the United Nations Special Rapporteur on extrajudicial, summary or arbitrary executions (SR SUMX) on behalf of the Al Salwi family, whose house was hit in September 2015 by a Saudi-led Coalition airstrike, which killed one family member, a teenage girl, and injured 10 others.