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On 20 December 2016, Alkarama sent an urgent appeal to the United Nations Working Group on Arbitrary Detention (WGAD) concerning the case of Mohamed Saad Zekillah, a young student who was arrested on 9 November 2016 by the Homeland Security Forces. He was secretly detained for 17 days, during which he was repeatedly tortured. He reappeared on 23 November 2016, when he was brought before the Public Prosecutor of Alexandria and charged with “belonging to a terrorist group”.

On 15 November 2016, the Egyptian Parliament proposed a flawed new draft NGO Law that replaces both the previous 2002 Law on Associations and the draft NGO Law that was presented by the government earlier this year.

On 3 November 2016, Alkarama alerted the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) of the case of Qadry Samy Zaky Abd Elrahman Muafy, a 49-year-old Egyptian citizen from Kafr Saad, Damietta Governorate who was abducted by members of the Police in Mit Ghamr, Dakahlia Governorate on 29 October 2016.

In late August 2016, the United Nations Working Group on Arbitrary Detention (WGAD), a group of independent experts, adopted Opinion n°42/2016; in which they qualify the detention of Ahmed Yousry Zaky, an Egyptian student who was arrested on 5 May 2015, as "arbitrary".

On 25 October 2016, Alkarama solicited the urgent intervention of the UN Working Group on Arbitrary Detention (WGAD) with regards to the final sentencing to 20 years in prison of former President Mohamed Morsi and other members of his staff, as a result of an Egyptian Court of Cassation's ruling on 22 October 2016.

On 19 October 2016, Alkarama referred to the United Nations Special Rapporteur on the Right to Health (SRH) the case of Ali Ahmed Ali Kerata, a 53-year-old employee who was arrested on 19 August 2014 in Damietta by members of the police forces falling under the Egyptian Ministry of Interior.

On 12 October 2016, Alkarama alerted the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) of several cases of disappearances in Egypt, concerning two young students, Ahmed Abdelrahim Hanafi Abdelrahim and Ahmed Atef Ahmed Abdelrahim Al Baghdadi, who recently went missing, as well as two men, Mohamed Gomaa Youssef Afifi and Abdelrahim Mahmoud Abd Annabi Alsayed, who have been disappeared for 10 months and two years respectively.

On 30 September 2016, Alkarama alerted the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) of the case of Ahmed Abdelrahman Ahmed Youssef Mabrouk, an Egyptian medical student who disappeared on 6 September.

On 8 September 2016, the Cabinet of Egypt approved an alarming draft NGO law that is currently under review by the Egyptian Council of State.

On 14 September 2016, Alkarama referred the case of Abdelrahman Gamal Mohamed Ahmed, an Egyptian medical student who disappeared on 25 August, to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID).