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On 25 October 2011, Syrian political activist Mahmoud Al Merhi was arrested at an Air Force Intelligence checkpoint in Homs and remains disappeared since.

On 30 November 2016, Alkarama and Human Rights Guardians referred to the Independent International Commission of Inquiry on the Syrian Arab Republic (CoI Syria) the case of Hani Hussein, a 37-year-old Syrian from Qamishli, who disappeared following his

Between November 2012 and March 2014 five Syrian men, all members of the same extended family originally from Hama, disappeared after their arrests by pro-Assad security forces.

On 18 November 2016, Alkarama and Human Rights Guardians wrote to the United Nations Working Group on Enforced Disappearances (WGEID) regarding the cases of two Syrian citizens from the village of Kafr al-Tun, who disappeared in the Governorate of Hama in western central Syria in 2012.

On 7 October 2013, Syrian political activist Asaad Al Mir– also known as Faeq Al Mir – was arrested in Damascus and has since been disappeared. His family is very concerned as he needs regular medical care due to health issues he suffers because of previous mistreatment in detention.

On 4 November 2016, the Working Group on the Universal Periodic Review (UPR) adopted a draft report containing the recommendations made by United Nations Member States to Syria during the State's review, which took place on 31 October 2016.

On 13 October 2016, Alkarama wrote to the United Nations Working Group on Enforced Disappearance (WGEID) regarding the case of a Lebanese citizen from the village of Brummana, in the Mount Lebanese Governorate, who disappeared in Syria in 1999. Arrested by the Lebanese Army in 1997, he was brought to an unknown place of detention and later transferred to the Syrian authorities.

On 10 August 2016, Alkarama and Human Rights Guardians wrote to the United Nations Working Group on Enforced Disappearances (WGEID) regarding the cases of five men arrested at checkpoints by members of security forces – one by the State Security F

On 1 March 2015, Moshen Al Hinnawi was running away from the fights between the Kurdish forces of the People's Protection Unit (YPG) and the Islamic State (IS) in the surroundings of his village in Al Hasakah governorate in Syria, when reached a YPG military checkpoint, where he was arrested. After this, his family lost track of him and their inquiries with the Kurdish authorities were ignored.

After almost two years of disappearance, on 6 June 2016, Raed Mahameed was able to receive a visit of his family in Al Malikiyah prison, in Syrian Kurdistan. His relatives had last visited him almost two years ago, on 4 November 2014 in the same detention centre before he had disappeared.