On 27 July 2014, Alkarama, in cooperation with Al Wissam Humanitarian Assembly, sent an urgent action to the United Nations Committee on Enforced Disappearances (CED) regarding the case of Ammar Al Dulaimi, a 32-year-old Iraqi citizen who disappeared in Hillah in the Babil Governorate following his arrest by the military forces in July 2014.

On 30 July 2015, Alkarama and Al Wissam Humanitarian Assembly submitted an urgent action to the United Nations Committee on Enforced Disappearances (CED) regarding the case of 12 Iraqi citizens abducted from their homes in Baghdad in April 2014 during a wave of arrests by SWAT forces and who remain disappeared since.

In February 2015, the family of Tewfik Djaou, disappeared since his abduction in 1997 in Constantine by agents of the Department of Intelligence and Security (DRS), asked Alkarama to address the United Nations Human Rights Committee (HRCtee) with a complaint regarding the disappearance of their son, in order to formally recognise the direct responsibility of the Algerian authorities and to obtain compensation.

On 6 May 2015, during its 54th session, the United Nations Committee against Torture (CAT) adopted a List of 34 issues prior to reporting (

On 28 July 2015, Alkarama and Human Rights Guardians sent a communication to the United Nations Working Group on Enforced Disappearances (WGEID) regarding the case of Hassan Saeed, an activist from Homs who disappeared following his arrest by members of the army and the Military Intelligence in August 2012.

On 22 July 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Arbitrary Detention (WGAD) regarding the continuous detention of Esraa Mahfouz Mohamed El Taweel, a 23-year-old student who has been detained arbitrarily since her arrest on 1 June 2015.

On 14 July 2015, Alkarama and Al Wissam Humanitarian Assembly sent a communication to the United Nations Committee of Enforced Disappearances (CED) regarding the disappearance of an Iraqi worker, Omar Saadoun Nayef Al Saab, following his abduction by government forces in Baghdad in June 2014.

On 22 July 2015, Alkarama referred the cases of 39 Libyan citizens, executed by the Zintan forces in the city of Kikla on 11 October 2014, to the United Nations Special Rapporteur on Extra-judicial, Summary or Arbitrary Executions (SR SUMX) and the Office of the Prosecutor of the International Criminal Court (

On 20 July 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the case of Mahmoud Tawfik Abdalaal, a 55-year-old former parliamentarian of the Freedom and Justice Party (FJP) – the political wing of the Muslim Brotherhood – disappeared since his arrest on 6 June 2015.

On 7 July 2015, Alkarama sent a communication to the United Nations Working Group on Arbitrary Detention (WGAD) regarding the case of Mohammed Mahdi Saleh Suleiman, a Palestinian teenager arrested on 15 March 2013 for "throwing stones" and arbitrarily detained pending trial to this day.