On 27 October 2015, Alkarama sent an urgent appeal to the United Nations Special Rapporteur on Torture (SRT) regarding the arrests, in September 2015, of Magdy Ahmed Abdelmoaty El Husseini and his son Ahmed Magdy Ahmed Abdelmoaty El Husseini, by the General Investigations Services.

On 23 October 2015, Alkarama sent an urgent appeal to the United Nations Special Rapporteur on Torture and other cruel, inhuman or degrading treatment or punishment (SRT) regarding the case of 20-year-old Egyptian student Omar Abdulrahman Ahmed Youssef Mabrouk, who disappeared after his arrest by State Security forces in Kuwait City in early October 2015.

On 26 October 2015, Alkarama sent a letter to the United Nations Working Group on Arbitrary Detention (WGAD) and the Special Rapporteur on Torture (SRT) regarding the adoption by the Egyptian authorities of new restrictive amendments to Law n°396 of 1956 on Prisons Regulations.

On 15 October 2015, Alkarama attended a pre-session briefing organised by the Delegation of the European Union to the United Nations, in view of the Mauritania's Universal Periodic Review (UPR), which will take place between 2 and 13 November 2015. Alkarama expressed its main concerns and recommendations, focusing on the practice of torture and the poor detention conditions, the authorities' failure to obtain transitional justice as well as their persecution of human rights defenders.

On 11 October 2015, the Djibouti Court of Appeal accepted the request to release the young members of the Union for National Salvation (USN) − the opposition coalition − and the Opposition Youth Movement (MJO), as well as two USN leaders, arrested on 18 September for having participated in a demonstration and arbitrarily detained in Gabode prison since 4 October following a first instance trial.

On 22 October 2015, Alkarama and Human Rights Guardians sent a communication to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the case of Abdo Hayani, a 32-year-old carpenter who disappeared after his arrest by State Security forces at a check

On 19 October 2015, Alkarama sent a communication to the United Nations Special Rapporteur on Extrajudicial, Summary or Arbitrary Executions (SR SUMMEX) regarding the case of 27 schoolgirls victim of two car bombs detonated at a checkpoint controlled by the Houthi-Saleh Coalition in the southwest city of Rada'a, Al Bayda Governorate, in December 2014.

On 20 October 2015, United Nations human rights experts urged the Qatari authorities to release Qatari poet Mohammed Al Ajami, who was sentenced to 15 years' imprisonment for writing and reciting a poem, at home, criticising Arab governments and praising the Tunisian revolution in 2010.

On 12 October 2015, Alkarama sent an urgent appeal the United Nations Working Group on Arbitrary Detention (WGAD) as well as an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the cases of two Yemeni citizens victims of the Houthi-Saleh Coalition in Sanaa.

On 9 October 2015, UPR Info held the pre-session meeting on Oman in view of the State's second review under the United Nations Universal Periodic Review (UPR), which will take place during the UPR's 23rd session in November.