In its Opinion No. 62/2021 issued on November 17, 2021, the UN Working Group on Arbitrary Detention (WGAD) considered the deprivation of liberty of Libyan citizens, Abdelhakim Imbarak Muhammad Ali and Sulaiman Muhammad Salim Sulaiman, as arbitrary. The victims had been arrested in the course of 2016 by the Special Deterrence Forces, government-backed militias known as "RADAA", before being detained at Mitiga detention center.

On 21 March 2022, Alkarama addressed the UN Working Group on Enforced Disappearances regarding the situation of Osama Muhammad Saleh AL GHAFIR AL OBEID, a colonel in the Libyan army taken prisoner on 07 december 2016 by General Khalifa Haftar's militias in the Sidra region (west, Tripoli).

The daughter of a Uighur activist detained in Saudi Arabia, Mr. Waili AIMOUDOULA, has raised her concerns over the deportation of her father and his friend, to urge them not to extradite to China, Mr. Waili AIMOUDOULA and his friend Mr. Ruze NUERMAIMAITI to the Chinese authorities, fearing they will be tortured and could lose their lives.

On 10 March 2022, Alkarama sent a communication to the UN Working Group on Arbitrary Detention (WGAD) regarding brigadier general Gamaleldeen Al Shaheed, who was arrested at his home on 29 June 2020 by the military intelligence services under the command of Lieutenant-General Abdel Fattah Al Burhan.

Saudi authorities have released prominent Saudi blogger Raif Badawi after his ten-year prison sentence ended. He was sentenced following an unfair trial and as punishment for exercising his right to freedom of expression. However, he remains today banned from travelling for another ten years.

On the evening of Monday, 7 March 2022, and after 67 days of detention, the Tunisian authorities released Mr Noureddine Al-Behairi, Ennahda parliamentarian and former Minister of Justice, as well as Mr Fathi Al-Baladi, former adviser to the Ministry of the Interior. Following their arrests, Alkarama had referred their cases to UN experts.

On 3 March 2022, Alkarama addressed the UN Working Group on Enforced Disappearances regarding the situation of Omar Maher Abdel Zaher EL DESOUKY, an Egyptian engineer who was arrested without a judicial warrant by security forces at Cairo airport on 20 December 2021 while on his way to Sweden.

On 24 February 2022, Alkarama addressed the UN Committee on Enforced Disappearances regarding the situation of three Iraqi brothers Aqil Khalil Hamid Ibrahim, Emad Khalil Hamid Ibrahim and Falah Khalil Hamid Ibrahim who were arrested at their home on 31 January 2014 by the military and have been missing since. While their family lost hope of finding them alive, one of the three brothers was seen in a detention center

Alkarama supports the call of the UN expert on the situation of human rights in Sudan, Adama Diang, to end the excessive use of force against peaceful protesters, lift the state of emergency in the country, release all remaining protesters and activists as well as investigate promptly and impartially all allegations of human rights violations.

On 22 February 2022, Alkarama addressed to the Special Rapporteur on the independence of judges and lawyers to inform him of the threats and intimidation to which the Lebanese lawyer Tarek Chindeb, known for his commitment to defend human rights in his country, is subjected.