On 5 November 2014, Egypt's second Universal Periodic Review (UPR) was held at the Palais des Nations in Geneva. This process aims to assess the human rights record of each United Nations' Member State by the Human Rights Council (HRC). Since its first review in February 2010, Egypt has undergone major political upheavals.

Alkarama welcomes the release, on 6 November 2014, of 19-year-old student, Aliaa Tarek Mohammad Alsayed, whose family had not heard from since her abduction by the Egyptian security forces at the Al Azhar University campus in Cairo on 20 October 2014.

On 20 October 2014, the United Nations Human Rights Committee (HRC) considered Israel's fourth periodic report.

On 4 November 2014 Alkarama sent a communication to the Special Rapporteur on the rights to freedom of peaceful assembly and of association as well as the Special Rapporteur on the situation of human rights defenders concerning the case of Said Ali Said Jadad, an Omani human rights defender victim of reprisal by the Omani security services.

On 31 October 2014, Alkarama sent a communication to the United Nations Working Group on Enforced and Involuntary Disappearances (WGEID) concerning the case of four persons disappeared since their arrest by the Syrian Military Intelligence on 24 November 2012.

On 28 October 2014, Alkarama sent a communication to the United Nations Working Group on Enforced and Involuntary Disappearances (WGEID) to raise the case of Qamar Awad, disappeared since her arrest by a patrol of the Syrian Air Intelligence Forces on 2 October 2012.

On 22 October 2014, Alkarama sent a communication to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the abduction of three Egyptian students.

On 16 October 2014, Alkarama and Al Wissam Humanitarian Assembly sent a communication to the Working Group on Enforced or Involuntary Disappearances (WGEID) to bring its attention to the case of Mohamad and Nouhad al Mashhadani, two brothers who disappeared since their arrest by members of the security forces in 2005.

On 17 October 2014, Alkarama sent a communication to the Special Rapporteur on Torture regarding the case of Karim Rhimi, a 22 year old student arrested on 19 September 2014 and severely tortured by the anti-terrorist squad.

On 20 October 2014, the United Nations Human Rights Committee (HRC) reviewed Israel's fourth periodic report at its 122th session held in Palais Wilson, Geneva.